Businesses in De Soto, Missouri

422 local businesses across 91 categories. 0.2% of everything listed in Missouri.

Quick answer

De Soto, MO has 422 businesses listed on USA Business Search in 91 categories across 2 ZIP codes. The most-listed are churches & places of worship, auto repair, general contractors.

Updated October 2026

Most listed in De Soto

Churches & places of worship Auto repair General contractors Hair salons Nonprofits & community Schools & tutoring Gas stations Farms & agriculture Gyms & fitness Insurance agents

Home services

General contractors (18)Landscaping & lawn care (5)HVAC & heating (5)Electricians (3)Plumbers (3)House cleaning (2)Concrete & paving (2)Locksmiths (2)Handyman services (1)Movers & hauling (1)Roofers (1)Flooring (1)Windows & doors (1)

Marketing & advertising

Printing & signs (2)Advertising agencies (1)

Auto

Auto repair (18)Gas stations (14)Car dealers (6)Tires (4)Car wash & detailing (4)Auto parts (4)Auto body & collision (3)Auto glass (2)Towing (2)

Food & drink

Pizza (8)Restaurants (8)Grocery & specialty food (5)Coffee shops & cafes (4)Bars & breweries (4)Mexican restaurants (3)Bakeries & desserts (2)

Health & medical

Senior living & home care (7)Pharmacies (4)Urgent care & hospitals (3)Doctors & clinics (2)Chiropractors (2)Wellness & alternative health (2)Dentists (1)Massage therapy (1)Eye care (1)Physical therapy (1)Counseling & therapy (1)

Beauty & personal care

Hair salons (18)Spas & med spas (5)Nail salons (5)Barbers (3)Dry cleaning & laundry (3)Tattoo & piercing (2)

Professional services

Business consulting (8)Accountants & tax (6)Shipping & couriers (3)Funeral homes (2)Engineering & architecture (1)

Real estate

Real estate agents (4)Self storage (4)Property management (2)

Finance & insurance

Insurance agents (9)Banks & credit unions (8)Financial advisors (5)Mortgage lenders (1)

Legal

Lawyers (2)

Shopping & retail

Florists & gifts (7)Phones & electronics (6)Hardware & garden (5)Thrift & consignment (4)Furniture & home decor (3)Clothing & boutiques (3)Sporting goods & outdoor (2)Liquor stores (1)Jewelry (1)

Pets

Pet grooming & training (7)Pet stores (4)Veterinarians (3)

Fitness & recreation

Gyms & fitness (9)Golf (3)Dance studios (2)Martial arts (1)Outdoor adventure & tours (1)

Hotels & travel

Hotels & lodging (4)Travel agencies (2)Campgrounds & RV parks (1)Vacation rentals (1)

Education & childcare

Schools & tutoring (14)Childcare & preschools (4)

Events & entertainment

Arts & entertainment (4)Event planning & weddings (2)

Business & industrial

Farms & agriculture (11)Propane & energy (4)Manufacturing & wholesale (4)

Community & faith

Churches & places of worship (37)Nonprofits & community (17)

More businesses in De Soto

Real estate agents (4)

Heartland Realty

122 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-0600 Website

Amanda Wall Realtor

122 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 524-2074 Website

Susie Jennewein, Real Estate Sales Agent

122 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 208-6067 Website

Shelley Ungerank, Premier Home Realty Group & Auction

111 W Pratt St, De Soto, MO 63020 · Claim or fix

Call (573) 631-2918

Pharmacies (4)

Medicine Shoppe

100 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-2202 Website

Walgreens

12977 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-8779 Website

Westland Health Mart Pharmacy

2020 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-1766 Website

Lin-kris Pharmacy Inc.

2020 Rock Rd # Hm, De Soto, MO 63020 · Claim or fix

Call (636) 586-1766

Tires (4)

Quick Lane Tire & Auto Center

12821 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 337-8473 Website

Purcell Tire and Rubber Company

300 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3301 Website

X Factor Tire & Auto LLC

112 W Kelley St, De Soto, MO 63020 · Claim or fix

Call (636) 525-4113 Website

Tire Shack

De Soto, MO 63020 · Claim or fix

Call (636) 208-1230

Pet stores (4)

Champion's Mercantile

2023 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-7773 Website

Tink’s Barkery & Pawtique

318 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5109

Jeffco Feed And Fertilizer Inc.

1600 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-5550

The Wicked B

101 Plaza Sq, De Soto, MO 63020 · Claim or fix

Call (636) 337-5345

Coffee shops & cafes (4)

Junction Cafe

106 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5484 Website

Just Be Kind Café

426 S Main St, De Soto, MO 63020 · Claim or fix

Call (314) 974-1364 Website

Flour De Lis Bakery

426 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-6200 Website

Pine Mountain Country Coffee House

122 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-6500

Bars & breweries (4)

Lachance Vineyards

12237 Peter Moore Ln, De Soto, MO 63020 · Claim or fix

Call (636) 586-2777 Website

North End Tavern

308 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-9751 Website

kozzys

516 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5218

Kozzys Lounge

46 Jefferson Sq, De Soto, MO 63020 · Claim or fix

Call (636) 337-5656

Thrift & consignment (4)

Corner Closet

128 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-9211 Website

Second Hand Rose's Resale

426 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-7050 Website

Pawn Guys

412 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-7296

Redfield's Flea Market

500 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3456

Arts & entertainment (4)

Melba Theatre

300 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-1900 Website

The Hearth Room

116 Easton St, De Soto, MO 63020 · Claim or fix

Call (314) 583-8333

Desoto Historic Tree Museum

Dewitt St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3680

Frogz Bowling Center

12796 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-4300

Hotels & lodging (4)

Timber Creek Resort

4800 US Highway 67, De Soto, MO 63020 · Claim or fix

Call (636) 586-7448 Website

Jefferson Square Inn

46 Jefferson Square, De Soto, MO 63020 · Claim or fix

Call (636) 586-8700 Website

Elks Lodge

689 Clarke St, De Soto, MO 63020 · Claim or fix

Call (636) 586-5068 Website

Arlington Bed & Breakfast Inn

207 E Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-0043 Website

Self storage (4)

Budget Self Storage

12521 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-8586 Website

Cornerstone Storage Desoto Llc

3655 Athena School Rd, De Soto, MO 63020 · Claim or fix

Call (888) 799-9998 Website

Fowler & Co. Storage

3655 Athena School Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-3013 Website

Nmi Mini Storage

6020 Nmi Dr, De Soto, MO 63020 · Claim or fix

Call (636) 586-8858

Propane & energy (4)

Blue Rhino Propane Exchange

1900 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-7943 Website

Blue Rhino Propane Exchange

518 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-1627 Website

Blue Rhino Propane Exchange

60 Jefferson Sq, De Soto, MO 63020 · Claim or fix

Call (636) 586-6696 Website

J&H Pump

5466 Victoria Cemetery Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-2515 Website

Manufacturing & wholesale (4)

Cottage Grove Quilt Company

200 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5407 Website

Haake Manufacturing Co

1607 Veterans Dr, De Soto, MO 63020 · Claim or fix

Call (636) 337-2400 Website

S. Bollinger & Associates

5462 Hillsboro Hematite Rd, De Soto, MO 63020 · Claim or fix

Call (636) 797-5820 Website

Scrub Oak Forge

14015 Hardin Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-5350

Car wash & detailing (4)

Auto Spa Speedy Wash

1704 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (866) 678-9274 Website

Top Gloss

13201 Summit Dr, De Soto, MO 63020 · Claim or fix

Call (636) 209-2756 Website

Auto Spa Car Wash

1704 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (866) 678-9274 Website

Red Bird Car Wash

200 Fletcher St, De Soto, MO 63020 · Claim or fix

Call (636) 586-2281

Auto parts (4)

NAPA Auto Parts

120 Fletcher St, De Soto, MO 63020 · Claim or fix

Call (636) 586-9111 Website

AutoZone

1899 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-5812 Website

O'Reilly Auto Parts

12991 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-9390 Website

Shanks Auto & Truck Service

13049 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-3001

Childcare & preschools (4)

Desoto Early Childhood Center

1812 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-1040 Website

Little Dragons Preschool

1812 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-1040 Website

St Rose of Lima School

523 S 4th St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3594 Website

Small Wonders Child Care Center South

1675 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-7033

Electricians (3)

De Soto Electrical Products

12561 State Highway 21, De Soto, MO 63020 · Claim or fix

Call (636) 337-3381 Website

Southeast Services, Inc.

13701 Southeast Dr, De Soto, MO 63020 · Claim or fix

Call (877) 485-7372 Website

De Soto Ozark Electric

1659 Veterans Dr, De Soto, MO 63020 · Claim or fix

Call (636) 586-5498

Mexican restaurants (3)

Coyol Mexican Bar & Grill

12967 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 586-7744 Website

El Lobo Rojo

106 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5509 Website

Taco Bell

12866 Highway 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-1370 Website

Furniture & home decor (3)

Fauth Appliance

312 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-6265 Website

Mueller's Furniture & Mattress

324 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3308 Website

Hearth & Home Store

116 Easton St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5200 Website

Barbers (3)

E J's Roffler Family Hair Center

502 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-8211 Website

Barbernation LLC

12913 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 243-8403 Website

Jake's Barber Shop

124 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5288

Shipping & couriers (3)

United States Postal Service

950 Boyd St, De Soto, MO 63020 · Claim or fix

Call (800) 275-8777 Website

UPS Access Point location

100 N Main St, De Soto, MO 63020 · Claim or fix

Call (800) 742-5877 Website

UPS Authorized Shipping Provider

1407 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-8092 Website

Urgent care & hospitals (3)

Joachim Platten Ambulance Hse

2926 Parthenon Dr, De Soto, MO 63020 · Claim or fix

Call (636) 586-2520 Website

Valle Ambulance District

12363 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 586-2132 Website

Valle Ambulance Station

1540 Hillcrest Dr, De Soto, MO 63020 · Claim or fix

Call (636) 586-8814

Dry cleaning & laundry (3)

DeSoto Laundry

410 N Main St, De Soto, MO 63020 · Claim or fix

Call (314) 520-3025

All Ways Washing

209 Boreas Dr, De Soto, MO 63020 · Claim or fix

Call (573) 315-8687

De Soto Laundromat

60 Jefferson Sq, De Soto, MO 63020 · Claim or fix

Call (636) 586-8880

Plumbers (3)

All Weather Sewer Service, Inc.

5300 Lazy Acres, De Soto, MO 63020 · Claim or fix

Call (636) 797-2345 Website

Warncke Plumbing

3869 Warncke Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-2805 Website

Jones Plumbing Service

12011 Castle Ranch Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-3799

Auto body & collision (3)

Pettus Automotive Collision Center

12821 MO Hwy 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-2639 Website

Tony's Paint & Body Shop

4825 State Rd V, De Soto, MO 63020 · Claim or fix

Call (636) 337-6237 Website

American Revival AutoBody & Repair

102 W Miller St, De Soto, MO 63020 · Claim or fix

Call (636) 208-4974

Golf (3)

Desoto Country Club golf course

1000 Lakeshore Dr, De Soto, MO 63020 · Claim or fix

Call (636) 337-5143 Website

Knight’s Flight Disc Golf Club

13225 State Rd E, De Soto, MO 63020 · Claim or fix

Call (636) 586-2594 Website

Cottonwood Golf Course

1000 Lakeshore Dr, De Soto, MO 63020 · Claim or fix

Call (636) 586-8803 Website

Clothing & boutiques (3)

Cato Fashions

12878 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 586-3686 Website

Styles With Sue

1135 N 7th St, De Soto, MO 63020 · Claim or fix

Call (636) 208-9610 Website

Lola B's Boutique

210 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5826

Veterinarians (3)

DeSoto Veterinary Hospital: Elizabeth J. Ryan, DVM

13909 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 586-3572 Website

PetVet Vaccination Clinic

60 Jefferson Sq, De Soto, MO 63020 · Claim or fix

Call (800) 427-7973 Website

VIP Petcare

60 Jefferson Sq., De Soto, MO 63020 · Claim or fix

Call (636) 586-6696

Auto glass (2)

Anytime AutoGlass

4138 Harmony Hills Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-0704 Website

Auto Plaza Collision Center

4605 State Road Y, De Soto, MO 63020 · Claim or fix

Call (636) 586-2639 Website

Printing & signs (2)

Fortune 5 Sign Co.

2360 Yellow Rock W, De Soto, MO 63020 · Claim or fix

Call (314) 540-7172 Website

Designs Express

817 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-5698 Website

Property management (2)

Sycamore Hills

1111 Cedar Valley Ct, De Soto, MO 63020 · Claim or fix

Call (636) 586-8780 Website

La Belle Vie

4800 US Highway 67, De Soto, MO 63020 · Claim or fix

Call (573) 415-3888 Website

Event planning & weddings (2)

Arlington Event Center

207 E Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-6109 Website

The Gathering Room

116 N Main St, De Soto, MO 63020 · Claim or fix

Call (314) 609-2939

Travel agencies (2)

Sunray's Travel

610 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-9131 Website

De Soto Railroad Employees Memorial

1608 Ronny Dr, De Soto, MO 63020 · Claim or fix

Call (636) 586-8366

Tattoo & piercing (2)

Foxes Den Tattoo

110 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 337-5197

Hezekiah Kustoms Tattoos

5345 State Rd H, De Soto, MO 63020 · Claim or fix

Call (636) 209-8370

Sporting goods & outdoor (2)

Caldwell Outdoor Equipment

1914 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-9607 Website

St. Louis Equipment - Jeff Co

13055 MO-21, De Soto, MO 63020 · Claim or fix

Website

Doctors & clinics (2)

Desoto Family Practice

12 Jefferson Square, De Soto, MO 63020 · Claim or fix

Call (636) 586-6685 Website

Midwest Medical Practitioners

120 Boyd St, De Soto, MO 63020 · Claim or fix

Call (636) 282-0380 Website

Funeral homes (2)

Dietrich-Mothershead Funeral Home, Inc.

220 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3337 Website

Mahn Funeral Home

900 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-2288 Website

Chiropractors (2)

Desoto Chiropractic

112 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-4226 Website

Madison's Chiropractic Care

5300 Victory Farm Rd, De Soto, MO 63020 · Claim or fix

Call (785) 626-0181

House cleaning (2)

Quality Cleaning and Restoration

14106 Timberline Dr, De Soto, MO 63020 · Claim or fix

Call (636) 337-5885 Website

Upkeep Techniques

11821 Castle Ranch Rd, De Soto, MO 63020 · Claim or fix

Call (314) 698-1929 Website

Dance studios (2)

Bordeau Dance Studio

408 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-8755 Website

Center Stage Dance Studio

508 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-7844 Website

Wellness & alternative health (2)

WW "Formerly Weight Watchers"

1651 Veterans Dr, De Soto, MO 63020 · Claim or fix

Call (800) 651-6000 Website

Healing My Way LLC

743 Sunset Hvn, De Soto, MO 63020 · Claim or fix

Call (636) 535-3314 Website

Concrete & paving (2)

No Limit Contracting

15737 State Road T, De Soto, MO 63020 · Claim or fix

Call (314) 827-1737 Website

B L Haverstick Concrete Llc

3195 Oakvale Rd, De Soto, MO 63020 · Claim or fix

Call (314) 580-0482 Website

Bakeries & desserts (2)

Flour•De•Lis Bakery

12909 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 586-6200 Website

DeSoto Donuts

2060 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 337-5052

Locksmiths (2)

Minute Key

12862 State Route 21, De Soto, MO 63020 · Claim or fix

Call (636) 251-3742 Website

KeyMe Locksmiths

12862 MO-21, De Soto, MO 63020 · Claim or fix

Call (636) 630-9379 Website

Lawyers (2)

Metro Bail Bonds

116 N 2nd St, De Soto, MO 63020 · Claim or fix

Call (888) 547-9330 Website

Gebhardt Real Estate & Legal Services

1720 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-4545

Towing (2)

J Lewis Towing

4100 Wilkinson Rd, De Soto, MO 63020 · Claim or fix

Call (314) 971-8980 Website

Steve's Auto Repair & Towing

4088 Athena School Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-4465

Dentists (1)

Douglas P Kummer Dds

704 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3388 Website

Handyman services (1)

Superior Painting

4734 State Road Y, De Soto, MO 63020 · Claim or fix

Call (314) 556-5749 Website

Movers & hauling (1)

U-Haul Neighborhood Dealer

1813 Rock Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-5806 Website

Martial arts (1)

Rising Star Martial Arts

414 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-7482 Website

Advertising agencies (1)

Utilix

116 N 2nd St, De Soto, MO 63020 · Claim or fix

Call (636) 481-5111 Website

Massage therapy (1)

Mending Muscles Therapeutic Massage

112 N Main St, De Soto, MO 63020 · Claim or fix

Call (314) 422-8913 Website

Eye care (1)

DeSoto Vision Care

126 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-5406 Website

Engineering & architecture (1)

Boyle Debra Drafting Service

1625 Mothershead Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-5566

Campgrounds & RV parks (1)

Camp Neotez

6266 Big River Heights Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-9756 Website

Roofers (1)

Custom Guttering Inc.

3250 Old County Rd, De Soto, MO 63020 · Claim or fix

Call (636) 586-2119

Liquor stores (1)

Byte Federal Bitcoin ATM (1 Stop Wine & Spirits)

605 S 2nd St, De Soto, MO 63020 · Claim or fix

Call (786) 686-2983 Website

Physical therapy (1)

De Soto Physical Therapy

702 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3887 Website

Jewelry (1)

McKinley Jewelers

308 S Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3342 Website

Flooring (1)

Quintin's Carpet & Tile

400 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-3330 Website

Windows & doors (1)

Ron's Glass Company

4730 State Rd H, De Soto, MO 63020 · Claim or fix

Call (636) 789-4443 Website

Counseling & therapy (1)

Theresa A Palmer

605 S 2nd St, De Soto, MO 63020 · Claim or fix

Call (636) 586-4655 Website

Mortgage lenders (1)

Tower Loan

310 N Main St, De Soto, MO 63020 · Claim or fix

Call (636) 586-6813 Website

Outdoor adventure & tours (1)

Missouri Park Adventures

13041 State Highway 104, De Soto, MO 63020 · Claim or fix

Call (636) 586-2995 Website

Vacation rentals (1)

Ridgetop Cabin

14026 Kingsland Rd, De Soto, MO 63020 · Claim or fix

Call (314) 270-3756 Website

Common questions

How many businesses are listed in De Soto, Missouri?

USA Business Search lists 422 businesses in De Soto across 91 categories. The most-listed are churches & places of worship, auto repair, general contractors.

Which ZIP codes does De Soto cover?

Listings include ZIP codes 63020, 63048.

How do I check that a De Soto business is legitimate?

Search the state's business registry and licensing boards. Our Missouri business lookup guide links each official search.

How do I add my business?

It's free: use Add your business. Owners can also claim and fix an existing listing.

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